6. Lil Bub
Lil Bub may come from humble beginnings – she was the runt of a feral mom’s litter – but her cute perma-litten appearance has won the hearts of millions of people around the world.
Lil Bub has several health issues that contribute to her adorableness. She suffers from osteopetrosis, has several genetic mutations, is toothless and has a misaligned lower jaw. In addition, because of these problems, her tongue is always protruding from her mouth. However, this sweet little girl has her own documentary, her own book, Facebook page, website and also over 462,000 Instagram followers.